Faculty/Staff Directory
John Shim, Ph.D.
Assistant Professor of Chemistry
- School of Arts & Sciences, Department of Physical Sciences
Room 232
650 College Dr. Dalton, GA 30720
Office Hours
Fall 2020
Tue: 9:25 am – 12:05 pm
Thurs: 1:40 pm – 4:00 pm
jshim@daltonstate.edu
706.272.2580
Degrees
Ph.D. University of Georgia
M.S. Seoul National University
B.S. Seoul National University
Biography
My area of expertise is computational modeling and molecular dynamics simulations. For more than two decades my laboratory’s research has contributed to the understanding of the structure activity relationship (SAR) and the mechanisms of action of many biomedically important proteins, in particular the brain cannabinoid (CB1) receptor, with the overall goal of contributing to the development of therapeutic agents. Currently, my major research focus is upon understanding CB1 receptor conformational changes by allosteric binding, which may alter its pharmacological profile.
Since I strongly support undergraduate student involvement in research (see below), any student who has a passion or curiosity about biomedical research, please contact me!
Academic Advisor
Course Name/Overview
| Course Name | Course Overview |
|---|---|
| CHEM 1211K | |
| CHEM 4900 | |
| CHEM 4960 | |
| CHEM 1212K |
Achievements
Grant awards:
NIDA K grant award (2007-2011)
XSEDE (National Science Foundation) supercomputer resource awards (2008-2017)
Publications:
Shim, J.-Y. Prediction of essential binding domains for the endocannabinoid N-arachidonoylethanolamine (AEA) in the brain cannabinoid CB1 receptor. PLoS One. 2021, 16(6):e0229879.
Shim, J.-Y., Khurana, L., and Kendall, D. A. Computational analysis of the CB1 carboxyl-terminus in the receptor-G protein complex. Proteins, 2016, 84:532-543.
Wu S, Shim, J.-Y., Lee CJ, Pedersen LG. Do the crystallographic forms of prethrombin-2 revert to a single form in solution? Biophys. Chem. 2015, 203-204:28-32.
Shim, J.-Y., Lee, C. J., Wu, S., and Pedersen, L. G. A model for the unique role of the Factor Va A2 domain extension in the human ternary thrombin-generating complex. Biophys. Chem. 2015, 199:46-50.
Shim, J.-Y., Ahn, K. H., and Kendall, D. A. Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gaibg. J. Biol. Chem. 2013, 288, 32449-32465.
Yeyeodu, S. T., Kidd, L. C. R., Oprea, G. M., Vancleave, T. T., Shim, J.-Y., Kimbro, K. S. IRAK4 and TLR3 sequence variants may alter breast cancer risk among African-American women. Front. Immunol. 2013, 4:338.
Ahn, K. H., Mahmoud, M. M., Shim, J.-Y., and Kendall, D. A. Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor one (CB1). J. Biol. Chem. 2013, 288, 9790-9800.
Shim, J.-Y., and Padgett, L. Functional residues essential for the activation of the CB1 cannabinoid receptor. Methods Enzymol. 2013, 520, 337-355.
More About Me
Undergraduate Research Student Supervision through CHEM4960
-Spring 2021: Dawson Hunnicutt (chemistry) and Angie Lee (biology)
-Spring 2020: Arianna Fisher (Chemistry), Nashelly Hernandez (Chemistry) and Alvaro Cortez (Biology)
-Spring 2019: Anna Sission (biology), Ethan Pierce (biology), Trusha Patel (biology) and Avani Patel (biology)
-Summer 2018: Alyssa Wong (chemistry) – DS Foundation Scholarship for 2018 winner
-Fall 2018: Ethan Blair (biology), Haley Richards (chemistry), Anna Sission (biology) and Alyssa Wong (chemistry)
-Spring 2018: Daniel Satterfield (biology) and Alyssa Wong (chemistry)
-Fall 2017: Bhavna Bhan (biology) and Daniel Satterfield (biology)
-Spring 2017: Jonathan Fredrick Schwan (physics) - DS Foundation Scholarship for 2017 winner
-Fall 2016: Jonathan Fredrick Schwan (physics), Carolina Moreno (chemistry), Jose Ortiz (chemistry), Corey Painter (biology) and Pranav Singh (mathematics)
-Testimonial:
...You provided us with a great opportunity to understand what it entails to craft a well written manuscript, as well as teaching us about your area of interest...(Alvaro Cortez)
...It definitely was the highlight of my undergraduate studies. I learnt a lot about publishing scientific journals, the format and got to see firsthand the execution of a great body of scientific work. I enjoyed working on this with you all. Thank you for the opportunity to be a part of this...(Arianna Fisher)